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本文选用山梨醇作为试验糖,通过呼气氢试验测定小肠传递时间。30名服15g山梨醇的健康志愿者中,26名呼气氢含量明显升高(△H2>5μmol/L);其中18名健康志愿者服山梨醇泛影葡胺液后,16名当泛影葡胺到达回盲部后产氢明显增高。采用呼气氢试验研究黄连素对人体小肠传递时间的影响,20名健康志愿者基础小肠传递时间为71.10±22.04min,口服1.2g(0.4g,每日3次)黄连素后,明显延长至98.25±29.03min(P<0.01)。实验结果表明,黄连素能延长小肠传递时间,它的抗腹泻作用至少部分与之有关。
Sorbitol was used as a test sugar in this study and the transit time of the small intestine was determined by a breath test. Among 30 healthy volunteers taking 15g of sorbitol, the hydrogen content of 26 breaths increased significantly (△H2>5 μmol/L); 18 healthy volunteers served as sorbitol after diatrizoate solution. Hydrogen production was significantly increased after meglumine reached the ileocecal unit. The effect of berberine on human intestinal transit time was studied with a breath hydrogen test. The time of basic small intestine delivery was 71.10±22.04 min in 20 healthy volunteers and 1.2 g (0.4 g, 3 times daily) of berberine was orally administered. After that, it was significantly prolonged to 98.25±29.03 min (P<0.01). The experimental results show that berberine can prolong the transit time of the small intestine, and its anti-diarrhea effect is at least partly related to it.