论文部分内容阅读
目的探索血糖对急性脑梗死患者预后的影响及与外周血细胞因子的相关性。方法分析2010年1月—2014年12月在义乌市急救中心接受治疗的急性脑梗死患者101例,以入院时即刻血糖(GLU)是否正常分为2组,观察组患者45例(GLU≥7.2 mmol/L),对照组患者56例(GLU<7.2 mmol/L)。结果 2组患者外周血IL-6、IL-10及TGF-β水平比较差异均无统计学意义(P>0.05)。观察组患者外周血TNF-α(t=3.080,P=0.003)、CRP(t=8.835,P<0.001)水平显著高于对照组。观察组患者血糖水平与外周血TNF-α呈现显著正相关,具有统计学意义(r=0.787;P<0.001);观察组患者血糖水平与外周血CRP呈现显著正相关,具有统计学意义(r=0.814;P<0.001)。观察组发病后3个月累积病死率显著高于对照组,相比较差异具有统计学意义(24.44%,11/45 vs.8.93%,5/56;χ2=4.207,P=0.042)。结论急性脑梗死患者血糖升高提示预后不良,且与外周血TNF-α、CRP水平呈现正相关关系。
Objective To explore the effect of blood glucose on the prognosis of patients with acute cerebral infarction and its correlation with peripheral blood cytokines. Methods A total of 101 patients with acute cerebral infarction who were treated in Yiwu Emergency Center from January 2010 to December 2014 were enrolled in this study. Immediately after admission, blood glucose (GLU) was divided into two groups. 45 patients in the observation group (GLU≥7.2 mmol / L) and 56 patients in the control group (GLU <7.2 mmol / L). Results There was no significant difference in the levels of IL-6, IL-10 and TGF-β between the two groups (P> 0.05). The levels of TNF-α (t = 3.080, P = 0.003) and CRP (t = 8.835, P <0.001) in the observation group were significantly higher than those in the control group. There was a significant positive correlation between blood glucose level and TNF-α in peripheral blood in observation group (r = 0.787; P <0.001). There was a significant positive correlation between blood glucose level and CRP in peripheral blood in observation group (r = 0.787; = 0.814; P <0.001). The cumulative mortality of observation group 3 months after onset was significantly higher than that of the control group, with significant difference (24.44%, 11/45 vs.8.93%, 5/56; χ2 = 4.207, P = 0.042). Conclusion The elevated blood glucose in patients with acute cerebral infarction suggests a poor prognosis and a positive correlation with the levels of TNF-α and CRP in peripheral blood.