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环孢菌素(CyA)可能引起与药物有关的肌病。本文报道3例心脏移植后肌活检异常,并就CyA 引起肌病的可能作用进行讨论。例1:男性33岁,扩张性心肌病,心脏移植后为防止免疫排斥反应,以硫唑嘌呤150mg/d,CyA 200～240mg/d 及强的松5mg/d 治疗共4个月。三次轻度免疫排斥反应曾用皮质类甾醇治疗,并服用enalapril 20mg/d。移植后15个月主诉双腿肌痛。神经学及肌电图(EMG)检查无异常,实验室检查(包括肌酶)除低血镁外,无显著异常。试用镁及阿司匹林治疗,症状日益加重。6个月后腿软弱且部分功能丧失,EMG 检查神经传导正常,休息状态下无纤维颤动电位,运动原单位
Cyclosporine (CyA) may cause drug-related myopathy. This article reports three cases of abnormal muscle biopsy after heart transplantation and discusses the possible role of CyA in causing myopathy. Example 1 Male 33-year-old with dilated cardiomyopathy treated with azathioprine 150 mg / day, CyA 200-240 mg / day, and prednisone 5 mg / day for 4 months after heart transplantation to prevent immune rejection. Three mild immunological rejection reactions were treated with corticosteroids and enalapril 20 mg / d. Fifteen months after transplantation complained of leg muscle pain. Neurology and electromyography (EMG) examination no abnormalities, laboratory tests (including muscle enzymes) in addition to low blood magnesium, no significant abnormalities. Trial of magnesium and aspirin treatment, the symptoms are getting worse. 6 months after the legs weak and some loss of function, EMG check normal nerve conduction, resting fibrillation without potential, the original unit of motion