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为了明确细胞增殖标记Ki-67和抗癌基因p53免疫反应性在皮肤鳞状细胞癌(CSCC)预后中的意义,作者运用单克隆抗体MIB-1(抗Ki-67)和DO-1(抗p53)免疫组化ABC法检测了160例CSCC患者175个肿瘤中Ki-67和p53的表达情况,并与多个具预后意义的组织病理学参数及临床指标作了比较。所有患者均存活,随访3年以上,平均5.2年,其中男123例,女37例,平均年龄67岁。发病部位依次为面、耳、手背、小腿、头皮和会阴部。143例(89.4％)手术后无症状,17例发生了淋巴结转移和局部复发,其中局
To clarify the significance of cell proliferation marker Ki-67 and anti-oncogene p53 immunoreactivity in the prognosis of cutaneous squamous cell carcinoma (CSCC), the authors used monoclonal antibodies MIB-1 (anti-Ki-67) and DO-1 (anti- The expression of Ki-67 and p53 in 175 tumors of 160 CSCC patients was detected by immunohistochemical ABC method, and compared with several histopathological parameters and clinical parameters with prognostic significance. All patients survived and were followed up for more than 3 years with an average of 5.2 years. Among them, 123 were males and 37 were females with an average age of 67 years. The lesions were facial, ear, back, calf, scalp and perineum. 143 cases (89.4%) were asymptomatic after surgery, and 17 cases had lymph node metastasis and local recurrence.