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多抗甲素是从甲型链球菌培养物中提取的一种生物反应调节剂（ＢＲＭ），在体外同种混合淋巴细胞反应（ＭＬＲ）中能抑制特异性ＣＴＬ的产生（对照组：ｌ０２±７６溶解单位，实验组：３４±３４溶解单位，Ｐ＝０．００５），而对ＮＫ活性并无显著影响。滴定实验测定，１０ｍｇ／Ｌ时抑制作用尤为明显。同时用ＢＡＬＢ／Ｃ和Ｃ５７Ｂ／Ｌ小鼠间行皮肤移植，结果表明多抗甲素能明显延长移植物存活时间，可望用于临床移植，其作用机理需进一步研究。
Polyactin A is a biological response modifier (BRM) extracted from Streptococcus mutans cultures and inhibits the production of specific CTLs in allo-mixed lymphocyte reaction (MLR) in vitro (control group: 76 units of dissolution, experimental group: 34 ± 34 units of dissolution, P = 0.005), with no significant effect on NK activity. Titration test, 10mg / L inhibitory effect is particularly evident. At the same time, BALB / C and C57B / L mice were used for skin grafting. The results showed that poly-A can prolong the survival time of the grafts, which is expected to be used in clinical transplantation. The mechanism needs further study.