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应用原子吸收光谱法测定了15例良性前列腺增生(BPH)和30例不同年龄正常男性血清、尿液、前列腺按摩后尿液(VB_3)内锌浓度。结果显示男性血清和VB_3锌浓度随年龄增长而下降,BPH患者血清和VB_3锌浓度、VB_3总锌量均显著高于相应年龄对照组。提示BPH患者存在锌代谢的改变。BPH患者血清双氢睾酮显著增高,其浓度与血锌水平呈正相关,提示两者在BPH发生中起一定作用。
The concentrations of zinc in urine, urine and prostate of 15 patients with benign prostatic hyperplasia (BPH) and 30 normal men of different ages were measured by atomic absorption spectrometry. The results showed that male serum and VB_3 zinc concentration decreased with age, BPH patients serum and VB_3 zinc concentration, VB_3 total zinc were significantly higher than the corresponding age control group. Prompt zinc metabolism in patients with BPH changes. BPH patients with serum DHT increased significantly, its concentration and serum zinc levels were positively correlated, suggesting that both play a role in the occurrence of BPH.