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美国 Dahl 等将一种促性腺激素释放激素(GnRH)拈抗剂:A_(?)-△~3-_(?)~1,P-F-D-Phe~2,D-T_1P~(3,6)GnRH,注入性腺功能减退的妇女,注入速度为30μg/kg/h。注入后8h,测定血清卵泡刺激素(FSH)生物活性,发现其活性仅为处理前水平的62％,而 FSH 免疫活性减少约为30％;生物活性与免疫活性之比(B/I)从处理前的1.8降至1.0。将血清样本进行层析和分级分离,发现在 GnRH 拮抗剂处理后,血清中出现免疫活性 FSH
Dahl and other United States will be a gonadotropin-releasing hormone (GnRH) antagonist: A _ (?) - △ ~ 3 -_ (~) ~ 1, PFD-Phe ~ 2, D-T_1P ~ (3,6) GnRH , Injection of hypogonadal women, injection speed of 30μg / kg / h. Eight hours after the injection, the biological activity of serum FSH was measured and found to be only 62% of the pre-treatment level, while the FSH immunoreactivity was reduced by about 30%. The ratio of bioactivity to immunocompetence (B / I) 1.8 before processing down to 1.0. Serum samples were subjected to chromatography and fractionation and found to have immunologically active FSH in serum following GnRH antagonist treatment