核因子κB(NF-κB)是一种广泛存在于哺乳动物细胞中、具有多向转录调节作用的蛋白质。近年研究表明,蛛网膜下腔出血后它在脑基底动脉内皮细胞以及周围的脑组织广泛高水平表达,与其调控的细胞因子(如肿瘤坏死因子α、白细胞介素1、白细胞介素6等)一起积极参与炎性反应、脑血管痉挛等生物进程。NF-κB的研究将为临床防治脑血管痉挛开辟新途径。 Nuclear factor κB (NF-κB) is a protein that widely exists in mammalian cells and has multi-directional transcriptional regulation. Recent studies have shown that after subarachnoid hemorrhage in the basilar artery endothelial cells and the surrounding brain tissue widely expressed at high levels, and its regulation of cytokines (such as tumor necrosis factor alpha, interleukin 1, interleukin 6, etc.) With active participation in inflammatory reactions, cerebral vasospasm and other biological processes. The study of NF-κB will open up new avenues for clinical prevention and treatment of cerebral vasospasm.