迄今为止,恶性疟疾仍然是严重威胁人类健康的传染性疾病之一。由于抗药性疟原虫的出现,研究安全、有效且廉价的恶性疟疾疫苗迫在眉睫。综述了当前在研究中的3种恶性疟疾疫苗,并从候选抗原性质、当前研究中的问题和抗原免疫原性等方面重点介绍了传播阻断型恶性疟疾疫苗的现状,为传播阻断型疟疾疫苗的研发提供了参考。 To date, falciparum malaria remains one of the contagious diseases that pose a serious threat to human health. Due to the emergence of drug-resistant Plasmodium, it is imminent to study the safe, effective and inexpensive malaria vaccine. The three types of falciparum malaria vaccines currently under study are reviewed. The current status of the vaccine against transmission of the type of malaria vaccine is highlighted in terms of the nature of candidate antigens, current research issues and antigenic immunogenicity, Vaccine R & D provides a reference.