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本文用氨苯砜(DDS)治疗盘状红斑痕疮(DLE)的疗效研究,是鉴于一患者用该药治疗有效而进行的。该患者系一28岁女性,患DLE持续四年,经外用皮质类固醇药物治疗,损害仅得部份控制。在用DDS治疗前数月,皮疹明显扩大,用甾固醇或羟氯奎宁治疗效果不佳。乃试用一疗程的DDS治疗,经两月后,皮疹几乎全部消退。有16例慢性DLE患者,两例已有皮疹一年或多年(病期平均数10.7年),临床表现均呈活动性,具有疤痕形成,5例已证明有一些系统性病征,15例皮疹均局限于面部,所有病例均由活体组织检查证实。全部患者在停用其它药物后四周给DDS,100mg/日,
This article with dapsone (DDS) treatment of discoid erythema sores (DLE) curative effect, in view of a patient with the drug treatment is effective. The patient, a 28-year-old woman with DLE for four years, was treated with topical corticosteroids, with only partial control of the damage. Months before treatment with DDS, the rash was significantly expanded with steroid or hydroxychloroquine treatment ineffective. Is to try a course of treatment of DDS, after two months, the rash almost all subsided. In 16 patients with chronic DLE, two had a skin rash of one year or more (an average of 10.7 years), were clinically active with scarring, 5 had proven systemic symptoms, and 15 had rashes Confined to the face, all cases confirmed by biopsy. All patients given DDS, 100 mg / day four weeks after discontinuation of other drugs,