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目的观察腺苷蛋氨酸(思美泰)联合舒肝宁治疗慢性乙型肝炎肝内胆汁淤积症的临床疗效。方法选择120例慢性乙型肝炎合并有胆汁淤积症患者,分为思美泰组、舒肝宁组和二者联合组各40例。思美泰组为思美泰500mg,每日两次静脉推注;舒肝宁组予以舒肝宁20m l,每日一次静脉滴注;联合组为同时应用舒肝宁和思美泰,疗程2周。治疗前后检测肝功能变化,并对比临床症状改善情况。结果思美泰组和舒肝宁组治疗后较治疗前肝功能均有明显改善(P<0.01),在TB IL下降幅度方面两组间有明显差异,思美泰组优于舒肝宁组(P<0.01),而联合组又优于另外两组。结论思美泰和舒肝宁注射液可以改善肝功能损害患者的症状,二者在黄疸的消退方面有显著的疗效,且以思美泰为显著。二者联合明显改善疗效,降低胆红素方面更为明显。
Objective To observe the clinical efficacy of adenosine methionine (Simei Tai) combined with Shuganing in treating chronic intrahepatic cholestasis of chronic hepatitis B. Methods A total of 120 patients with chronic hepatitis B complicated with cholestasis were enrolled and divided into three groups: Si-Mei-Tai, Shu-Gan-Ning and the combination of the two. Simei Thai group was Simei Tai 500mg, twice daily intravenous injection; Shuganing group Shuganing 20m l, once daily intravenous infusion; combination group for the same time the application of Shugan Ning and Simei Thai, treatment 2 weeks. Before and after treatment to detect changes in liver function, and to improve the clinical symptoms. Results The Smectite group and Shuganing group had significantly better liver function than those before treatment (P <0.01), and there was a significant difference between the two groups in the decline of TBIL (P <0.01), while the combination group was superior to the other two groups. Conclusion Simei Tai and Shugan Ning injection can improve the symptoms of patients with liver dysfunction, both in the regression of jaundice have a significant effect, and to Simei Tai was significant. The combination of both significantly improved efficacy, lower bilirubin more obvious.