1914年Wenckebach报道一个疟疾患者经用金鸡钠树皮生物碱(主要含奎宁)治疗后,其心律失常能转复至正常窦性心律。1918年Frey发现,辛可宁、奎宁和奎尼丁在使心房颤动转复至正常节律方面具有相似的作用,其中奎尼丁作用最强。此后,奎尼丁就成为维持正常心律的最重要和有效的药物。除此之外,如普鲁卡因酰胺、苯妥英钠、利多卡因和β-肾上腺能阻滞剂心得安等都是临床 In 1914, Wenckebach reported that a malaria patient was able to regain normal sinus rhythm after treatment with goldenrod bark alkaloids (mainly quinine). In 1918 Frey found that cinchon, quinine and quinidine in the atrial fibrillation to return to normal rhythm has a similar role, of which quinidine has the strongest effect. Since then, quinidine has become the most important and effective drug to maintain normal heart rhythm. In addition, such as procainamide, phenytoin sodium, lidocaine and β-adrenergic blocker propranolol are all clinical