人类分娩发动的原因十分复杂,其中功能性孕激素撤退学说倍受关注。妊娠期间,高浓度孕激素维持子宫的静止状态,很多哺乳动物分娩时孕激素水平是下降的,但人类分娩发动时血中孕激素水平并不下降。目前认为,可能是孕激素受体表达异常导致孕激素功能下降。重点阐述孕激素核受体及膜受体的结构、亚型及表达,并对核受体及膜受体在分娩发动过程中的作用机制及其调节因素进行综述。 The reason why human birthing starts is very complicated, of which the theory of functional progestin withdrawal has drawn much attention. During pregnancy, high concentrations of progesterone to maintain the state of the uterus, many mammalian progestin levels during childbirth is declining, but when the human childbirth mothers serum progesterone levels do not decline. It is currently believed that abnormal progesterone receptor expression may lead to decreased progesterone function. It focuses on the structure, subtypes and expression of progesterone nuclear receptors and membrane receptors, and reviews the mechanisms and regulatory factors of nuclear receptors and membrane receptors during labor onset.