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目的 探讨骨肉瘤患者红细胞免疫功能状态与T淋巴细胞亚群改变的关系。方法 测定35例骨肉瘤患者红细胞补体受体花环率 (C3 bRR)、红细胞免疫复合物花环率 (RICR)、红细胞免疫促进因子 (RFER)、红细胞免疫抑制因子 (RFIR)和T淋巴细胞亚群 (CD3 、CD4 、CD8)的功能状态。结果 骨肉瘤患者C3 bRR、RFER、CD3 、CD4 较正常对照组降低 (P <0 0 5 ) ,而RICR、RFIR、CD8则较正常对照组升高 (P <0 0 5 )。骨肉瘤患者C3 bRR与CD4 /CD8比值呈正相关。结论 骨肉瘤患者红细胞免疫功能低下 ,T淋巴细胞亚群比例失调 ,两者关系密切
Objective To investigate the relationship between erythrocyte immune status and T lymphocyte subsets in osteosarcoma patients. Methods The expressions of C3 bRR, RICR, RFER, RFIR and T lymphocyte subsets in 35 patients with osteosarcoma were determined. CD3, CD4, CD8) functional status. Results C3 bRR, RFER, CD3 and CD4 in osteosarcoma patients were lower than those in normal controls (P <0.05), but RICR, RFIR and CD8 were higher in patients with osteosarcoma than in controls (P <0.05). There was a positive correlation between C3 bRR and CD4 / CD8 in osteosarcoma patients. Conclusion Osteosarcoma patients with low immune function of red blood cells, T lymphocyte subsets imbalance between the two are closely related