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肺癌的病死率在我国位于恶性肿瘤的前列。细胞增殖周期调控异常是恶性肿瘤的一个重要特征[1],调控细胞周期进程分子机制的核心是细胞周期蛋白依赖性激酶(cyclin-de-pendenet kinases,CDK)的活性表达与调控,CDK与细胞周期蛋白1(cyclin D 1)等相结合而激活蛋白激酶活性推动细胞从
The mortality rate of lung cancer in China is at the forefront of malignancy. The abnormal regulation of cell cycle is an important feature of malignant tumor [1]. The core of the molecular mechanism regulating the process of cell cycle is the expression and regulation of the activity of cyclin-de-pende kinases (CDK) The combination of cyclin D1 and other proteins activates protein kinase activity