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喹诺酮类药物是近年来发展十分迅速的抗菌药,该类药物按照骨架结构的不同,大体可分为吡啶并吡啶酮酸,嘧啶并吡啶酮酸,缯啉酸类和喹啉酸类四大类。80年代以来,以喹啉酸为母核骨架的氟喹诺酮类药物大量开发研究并广泛应用于临床。此类药物具有抗菌谱广,抗菌作用强,组织内和细胞类药物浓度高,血半衰期较长,使用方便,不必做过敏试验,对肝肾功能的影响相对较小,药源丰富,患者耐受性好及价格相对较低等特点,因此成为医药工业开发研究的热点。目前在国内临床应用已很普遍,但是随着其应用的日益广泛,对其不良反
Quinolones are rapidly developing antimicrobial agents in recent years. According to the skeleton structure, quinolones can be divided into four categories: pyridopyridyl acid, pyrimidopyridone acid, nicotinic acid and quinolinic acid . Since the 1980s, quinolinic acid as the main nuclear skeleton of fluoroquinolones a large number of development and research and widely used in clinical. Such drugs have broad antibacterial spectrum, strong antibacterial effect, high concentrations of intracellular and cellular drugs, long blood half-life, easy to use, do not have to do allergy tests, liver and kidney function is relatively small, rich source of drug resistance Good sex and relatively low prices and other characteristics, it has become the focus of the development of the pharmaceutical industry. Currently in clinical application has been very common in the country, but with its increasingly wide range of applications, its adverse reactions