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甲状腺功能亢进性周期性麻痹(TPP)是亚洲人群中最常见的继发性低钾性周期性麻痹,在西方国家发病率较低。其诱发因素多样,具体发病机制尚不明确,近年发现部分患者携带钾离子通道蛋白基因突变,提示离子通道的原发缺陷在TPP发病机制中可能扮演一定角色。TPP典型的临床表现为反复发作性低钾性肢体瘫痪伴甲状腺功能亢进,低钾及无力可经抗甲状腺毒性治疗后得到改善。文中综合近年文献,从TPP的流行病学、发病机制、临床表现、诊断以及治疗方面予以综述。
Hyperthyroidism Periodic paralysis (TPP) is the most common secondary hypokalemic periodic paralysis in the Asian population, with a low prevalence in Western countries. The evoked factors are diverse, the specific pathogenesis is not clear, in recent years found that some patients carry potassium ion channel protein gene mutations, suggesting that the primary defect of ion channels in the pathogenesis of TPP may play a role. The typical clinical manifestations of TPP recurrent hypokalemic limb paralysis with hyperthyroidism, hypokalemia and weakness can be treated with anti-thyroid toxicity improved. Based on the literature in recent years, this review summarizes the epidemiology, pathogenesis, clinical manifestation, diagnosis and treatment of TPP.