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处女型 CD4+ T细胞受特异性抗原刺激 ,分化为 Th 1和 Th 2细胞。Th 1产生 IFNγ,诱导产生细胞免疫。 Th 2产生 IL -4、IL -5 ,诱导产生过敏反应。这两个亚群之向末梢组织的浸润有特异性 ,Th 1浸润于类风湿滑膜中等 ,Th 2则选择性地浸润于特应性皮炎部位 ,但其机制不明。1998年
Virgin CD4 + T cells are stimulated with specific antigens and differentiate into Th1 and Th2 cells. Th 1 produces IFNγ, inducing cellular immunity. Th2 produces IL-4, IL-5, inducing anaphylactic reactions. The infiltration of these two subpopulations into the peripheral tissue is specific, with Th 1 infiltrating into the rheumatoid synovial membrane and Th 2 selectively infiltrating the atopic dermatitis site, but the mechanism is unknown. 1998