论文部分内容阅读
目的研究多囊卵巢综合征(PCOS)患者内分泌及糖脂代谢特征,以指导临床治疗。方法依据2003年鹿特丹诊断标准纳入PCOS患者455例,按照体重指数和胰岛素抵抗指数分组,比较不同分类患者的性激素、血糖、胰岛素及血脂水平。结果 (1)肥胖组和非肥胖组分别为152例和303例,肥胖组PCOS患者T、FPG、FINS、2 h-PG、2 h-INS、HOMA-IR、TG、LDL、Apo-B高于非肥胖组,FSH、LH、HDL低于非肥胖组,差异有统计学意义(P<0.05);(2)胰岛素抵抗组217例(IR组)和非胰岛素抵抗组238例(NIR组),IR组PCOS患者BMI、FPG、FINS、2h-PG、2h-INS、HOMA-IR、TG高于NIR组,LH、HDL低于NIR组,差异有统计学意义(P<0.05)。结论 (1)非肥胖的PCOS患者表现为下丘脑-垂体-卵巢轴功能紊乱,肥胖的PCOS患者更容易出现胰岛素抵抗;(2)PCOS患者存在脂代谢异常,以肥胖型PCOS患者和胰岛素抵抗型PCOS患者血脂紊乱更为明显。
Objective To study the characteristics of endocrine and glycolipid metabolism in patients with polycystic ovary syndrome (PCOS) to guide the clinical treatment. Methods 455 PCOS patients were included in the diagnostic criteria of Rotterdam in 2003. The patients were divided into groups according to body mass index and insulin resistance index to compare the levels of sex hormones, blood glucose, insulin and blood lipid among different categories. Results (1) The obesity group and the non-obesity group were 152 cases and 303 cases respectively. The obese patients with PCOS had higher levels of T, FPG, FINS, 2 h-PG, 2 h-INS, HOMA-IR, TG, LDL and Apo-B (2) Insulin resistance group 217 cases (IR group) and non-insulin resistance group 238 cases (NIR group) in the non-obese group, FSH, LH, HDL lower than non-obese group, the difference was statistically significant The levels of BMI, FPG, FINS, 2h-PG, 2h-INS, HOMA-IR and TG in IR group were higher than those in NIR group and lower in LH and HDL group than in NIR group (P <0.05). Conclusions (1) Non-obese patients with PCOS manifest hypothalamus-pituitary-ovarian axis dysfunction, and obese patients with PCOS are more likely to develop insulin resistance. (2) Patients with PCOS have abnormal lipid metabolism. In obese patients with PCOS and insulin resistance PCOS patients with dyslipidemia is more obvious.