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目的:目前尚不清楚先兆子痫是由孕前因素还是妊娠因素所引起。本研究通过在中国湖南地区建立孕前队列以阐明先兆子痫的病因。方法:本研究拟在湖南浏阳地区招募5000对半年内有怀孕打算的未孕夫妇,并追踪研究对象的怀孕、分娩及产后情况。结果:目前本孕前队列共招募了1915对未孕夫妇。与孕前相比较,产妇的收缩压和舒张压在孕中早期有所下降,然而在孕后期有所上升。结论:孕前队列的建立将对孕期先兆子痫及产后心血管疾病的预防发挥重要的理论和实际意义。
PURPOSE: It is unclear whether pre-eclampsia is caused by pre-pregnancy or pregnancy-related factors. This study clarifies the etiology of preeclampsia by establishing prenatal cohorts in Hunan, China. Methods: This study intends to recruit 5000 in Liuyang area of Hunan pregnant women intending to conceive within six months of pregnancy, and follow-up study of pregnancy, childbirth and postnatal conditions. Results: At present, 1915 pairs of non-pregnant couples were enrolled in the pre-pregnancy cohort. Compared with before pregnancy, maternal systolic and diastolic blood pressure decreased in early pregnancy, however, increased in the second trimester. Conclusion: The establishment of pre-pregnancy cohort will play an important theoretical and practical significance in the prevention of pre-eclampsia and postpartum cardiovascular disease during pregnancy.