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目的： 评价宫颈癌前病变及宫颈癌与宫颈人乳头状瘤病毒 （ Ｈ Ｐ Ｖ） 感染的关系。方法： 对１５８ 例宫颈涂片异常患者进行阴道镜下宫颈多点活检同时行宫颈 Ｐ Ｃ Ｒ Ｈ Ｐ Ｖ Ｄ Ｎ Ａ 检测。结果： 慢性宫颈炎、低度鳞状上皮内病变 （ Ｌ Ｓ Ｉ Ｌ） 、高度鳞状上皮内病变 （ Ｈ Ｓ Ｉ Ｌ） 和宫颈癌的 Ｈ Ｐ Ｖ １６／１８ 感染率分别为８６６ ％ 、３４６９ ％ 、６８８９ ％ 和８３３３ ％ ， Ｈ Ｓ Ｉ Ｌ 的 Ｈ Ｐ Ｖ １６／１８ 感染率明显高于 Ｌ Ｓ Ｉ Ｌ （ Ｐ＜ ００１） 。 Ｈ Ｐ Ｖ １６／１８ （ ＋ ） 的 Ａ Ｓ Ｃ Ｕ Ｓ 中 Ｈ Ｓ Ｉ Ｌ 检出率明显高于 Ｈ Ｐ Ｖ １６／１８ （ － ） ， Ｈ Ｐ Ｖ １６／１８ （ ＋ ） 的 Ｌ Ｓ Ｉ Ｌ 中 Ｈ Ｓ Ｉ Ｌ 检出率明显高于 Ｈ Ｐ Ｖ １６／１８ （ － ） 。结论： 宫颈癌前病变、宫颈癌与 Ｈ Ｐ Ｖ １６／１８ 感染密切相关， 随着病变程度的加重， Ｈ Ｐ Ｖ １６／１８检出率升高， 提示 Ｈ Ｐ Ｖ １６／１８ 为宫颈癌的高危因素。宫颈 Ｐ Ｃ Ｒ Ｈ Ｐ Ｖ １６／１８ Ｄ Ｎ Ａ 的检测可用于 Ａ Ｓ Ｃ Ｕ Ｓ、 Ｌ Ｓ Ｉ Ｌ 患者活检前的筛查。
Objective: To evaluate the relationship between cervical precancerous lesions and cervical cancer and human papillomavirus (HPV) infection. Methods: 158 cases of cervical smear abnormalities underwent colposcopy multi-point biopsy cervix P C R H P V D N A detection. Results: The infection rates of chronic cervicitis, low-grade squamous intraepithelial lesion (L S I L), high-grade squamous intraepithelial lesion (H S I L) and cervical cancer were 866% , 3469%, 6889% and 8333%, respectively. The infection rate of H P V 16/18 in H S I L was significantly higher than that in L S I L (P <001). The detection rate of H S I L in A S C U S of H P V 16/18 (+) was significantly higher than that of H P V 16/18 (-) and H P V 16/18 (+) The detection rate of H S I L was significantly higher than that of H P V 16/18 (-). Conclusion: Cervical precancerous lesions and cervical cancer are closely related to the infection of H P V 16/18. The detection rate of H P V 16/18 increases with the severity of the lesions, suggesting that H P V 16/18 is a marker of cervical cancer High risk factors. Cervical P C R H P V 16/18 D N A test can be used for S C U S, L S I L patients before biopsy screening.