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目的探讨玄麦甘桔颗粒减低早期鼻咽癌同步放化疗放射反应的临床效果。方法将60例早期鼻咽癌同步放化疗患者随机均衡地分为治疗组和对照组各30例。对照组随病情变化予以抗感染等对症支持治疗;治疗组在对照组治疗基础上加服玄麦甘桔颗粒,比较两组患者的客观疗效、放化疗完成率、放射反应等指标。结果治疗组客观疗效为93.3%,与对照组(90.0%)比较,差异无统计学意义(P=0.582);治疗组放化疗完成率为96.7%,与对照组(73.3%)比较,差异有统计学意义(P<0.05);治疗组放射反应明显低于对照组,差异有统计学意义(P<0.05)。结论玄麦甘桔颗粒有显著的减毒作用,对减轻早期鼻咽癌同步放化疗患者的放射反应、缓解急性放射性口腔黏膜炎症状具有显著疗效,值得临床推广应用。
Objective To investigate the clinical effect of Xuanmaigan Ganjie granule in reducing the radiation response of concurrent nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy. Methods Sixty patients with early stage nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy were randomly divided into treatment group (n = 30) and control group (n = 30). The patients in the control group were treated with anti-infection and other symptomatic treatments. The treatment group was given Xuanmaigan Ganjie granules on the basis of the control group, and the objective curative effect, completion rate of radiotherapy and chemotherapy, and radiation response were compared between the two groups. Results The objective curative effect of the treatment group was 93.3%, which was not significantly different from that of the control group (90.0%) (P = 0.582). The completion rate of radiotherapy and chemotherapy was 96.7% in the treatment group compared with 73.3% in the control group Statistical significance (P <0.05); Radiation response in treatment group was significantly lower than that in control group, the difference was statistically significant (P <0.05). Conclusion Xuanmaigangan Granule has a significant attenuation effect, which has a significant effect on alleviating radiation reaction and alleviating symptoms of acute radiation-induced oral mucositis in patients with early nasopharyngeal carcinoma and is worthy of clinical application.