目的:观察自拟清肝和胃饮联合马来酸曲美布汀片辨治肝胃郁热证功能性消化不良的临床效果。方法:选择就诊于本院的肝胃郁热证功能性消化不良患者204例为对象,随机分为对照组和观察组各102例。对照组患者给予马来酸曲美布汀片口服;观察组患者则加用自拟清肝和胃饮治之。比较两组治疗的临床疗效,评价中医证候积分及生活质量,监测用药前后血清一氧化氮(NO)、生长抑素(SS)、5-羟色胺(5-HT)及P物质(SP)水平。结果:观察组有效率92.1%高于对照组的78.4%(P<0.05);治疗后观察组中医证候积分显著低于对照组(P<0.05);经治疗后观察组患者情绪、躯体、角色、社会、认知等方面的生活质量评分显著高于对照组患者(P<0.05);治疗后观察组患者NO、SS、5-HT水平与对照组比较显著降低,而SP水平则显著升高(P<0.05)。结论:自拟清肝和胃饮联合马来酸曲美布汀片利于缓解肝胃郁热证功能性消化不良患者的临床症状,提高生活质量,疗效肯定,其机制与调控NO、SS、5-HT及SP水平以促进胃肠动力、加快胃肠蠕动有一定相关性。 Objective: To observe the clinical effect of self-made Qinggan and Weijin combined with trimebutine maleate tablet in treating functional dyspepsia of liver-stomach stagnation syndrome. Methods: A total of 204 patients with functional dyspepsia of hepatogastric febrile disease were selected as the subjects and randomly divided into control group and observation group of 102 cases each. Patients in the control group were given trimebutine maleate tablets orally; patients in the observation group were treated with self-made liver and stomach drink. The clinical efficacy of the two groups were compared to evaluate the TCM syndrome scores and quality of life. The levels of serum nitric oxide (NO), somatostatin (SS), serotonin (5-HT) and substance P (SP) . Results: The effective rate in the observation group was 92.1% (78.4%) of the control group (P <0.05). After treatment, the scores of TCM syndromes in the observation group were significantly lower than those in the control group (P <0.05) The scores of quality of life in the aspects of role, society and cognition were significantly higher than those in the control group (P <0.05). After treatment, the levels of NO, SS and 5-HT in the observation group were significantly lower than those in the control group, while the levels of SP were significantly increased High (P <0.05). Conclusion: The combination of Qinggan and Weijin with trimebutine maleate can relieve clinical symptoms and improve the quality of life in patients with functional dyspepsia of liver-stomach yin-heat syndrome. The mechanism and regulation of NO, SS, 5- HT and SP levels to promote gastrointestinal motility, accelerate gastric motility has some relevance.