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酮替芬又名噻哌酮(Ketotifen,Zaditen),近年来已在临床广泛应用,它的治疗作用很多,本文扼要概述它在儿科的应用。一、药理作用酮替芬是80年代新合成的一种抗组胺和抗过敏药。动物实验与临床观察结果,均证实酮替芬有以下药理作用:(1)抗组胺作用。给豚鼠静注酮替芬5分钟后,能抑制组胺诱发的支气管痉挛,其半数有效剂量(ED_(50))为0.037mg/kg,作用比吡咯醇胺(Clemastine)强3～4倍。(2)抗过敏作用。对马血清致敏的豚鼠预先静注酮替芬,再注射致敏原,则不易发生过敏性休克。(3)抑制磷酸二
Ketotifen, also known as Ketotifen (Zaditen), has been widely used clinically in recent years. It has many therapeutic effects. This article briefly outlines its application in pediatrics. First, the pharmacological effects Ketotifen is an anti-histamine and anti-allergic drugs newly synthesized in the 1980s. Animal experiments and clinical observations, both confirmed that ketotifen has the following pharmacological effects: (1) antihistamine effect. After intravenous ketotifen was given to guinea pigs for 5 minutes, histamine-induced bronchospasm was inhibited. The half effective dose (ED_ (50)) was 0.037 mg / kg, which was 3-4 times stronger than that of clemastine. (2) Anti-allergic effects. Horse serum-sensitized guinea pigs pre-intravenous ketotifen, then injection of allergens, is not prone to anaphylactic shock. (3) inhibit phosphate two