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研究了Ｌ－精氨酸（Ｌ－Ａｒｇ）对急慢性缺氧大鼠肺循环和脑血流的影响。一次注射Ｌ－Ａｒｇ４００ｍｇ·ｋｇ￣（－１）对急性缺氧性肺血管收缩反应（ＨＰＶ）无影响，而８００ｍｇ·ｋｇ￣（－１）有明显抑制作用；两种剂量的Ｌ－Ａｒｇ对缺氧性脑血流的变化均无显著影响。Ｌ－Ａｒｇ（３００ｍｇ·ｋｇ￣（－１）·ｄ￣（－１））能缓解慢性缺氧性肺动脉高压、肺血管阻力增高和右心肥厚，并抑制ＨＰＶ，但对脑血流无显著影响。ＮＯ合成酶抑制剂Ｌ－精氨酸甲酯可拮抗Ｌ－Ａｒｇ的作用，提示Ｌ－Ａｒｇ的作用可能与增加ＮＯ合成有关。
The effects of L-arginine on pulmonary circulation and cerebral blood flow in acute and chronic hypoxia rats were studied. One injection of 400mg · kg -1 of L-Arg had no effect on acute hypoxic pulmonary vasoconstriction (HPV), while 800mg · kg -1 (-1) had obvious inhibitory effect. L-Arg Oxygen cerebral blood flow changes have no significant effect. L-Arg (300 mg · kg -1 (-1) · d -1) could alleviate chronic hypoxic pulmonary hypertension, pulmonary vascular resistance and right ventricular hypertrophy and inhibit HPV, but had no significant effect on cerebral blood flow . L-arginine methyl ester, an NO synthase inhibitor, antagonized the effect of L-Arg, suggesting that L-Arg might be involved in the increase of NO synthesis.