目的:研究以自然周期作为子宫内膜准备方式对子宫内膜异位症(EMS)患者冻融胚胎移植(FET)妊娠结局的影响。方法:回顾性分析EMS患者353个FET周期,按EMS严重程度分组,A组:I~II期,120个周期;B组:III~IV期,233个周期;另将B组中囊肿复发的47个周期设为D组;而将输卵管因素不孕患者的300个FET周期纳入为对照组(C组),比较A、B、C组患者自然周期准备内膜的妊娠结局。结果:A、B、C组患者的种植率、活产率、继续妊娠率、流产率、妊娠期并发症率无统计学差异(P>0.05),且妊娠结局与EMS的分期无关。A、B、C组均没有出生缺陷儿。当高质量的胚胎移植时,卵巢内膜异位囊肿并不影响妊娠结局。B组较C组低出生体质量儿和早产儿的发生率高。结论:EMS患者自然周期准备内膜与输卵管性因素不孕患者有相似的妊娠结局,且与EMS严重程度无关,妊娠结局不受内膜异位囊肿的影响,是经济、高效的内膜准备方法。 OBJECTIVE: To study the effect of natural cycles as endometrial preparation on pregnancy outcomes of frozen-thawed embryo transfer (FET) patients with endometriosis (EMS). Methods: The 353 FET cycles of EMS patients were retrospectively analyzed. The patients were divided into two groups according to the severity of EMS. Group A: I to II, 120 cycles; Group B: III to IV, 233 cycles; 47 cycles were set as group D; 300 FET cycles of tubal factor infertility patients were included as control group (group C), and the natural cycle of endometrial pregnancy was compared in group A, B and C; Results: There was no significant difference in implantation rate, live birth rate, continuous pregnancy rate, miscarriage rate and pregnancy complication rate among groups A, B and C (P> 0.05). Pregnancy outcome was not related to the stage of EMS. There were no birth defects in groups A, B and C. When high-quality embryo transfer, ovarian endometriosis does not affect pregnancy outcome. The incidence of low birth weight children and premature children in group B was higher than that in group C. CONCLUSIONS: EMS patients have similar pregnancy outcomes in patients with spontaneous intima and tubal infertility, and are independent of EMS severity, and pregnancy outcomes are not affected by endometriosis, which is an economical and efficient method of endometrial preparation .