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肿瘤干细胞(cancer stem cells,CSC)是存在于肿瘤组织中的一小群具有干细胞性质的瘤细胞,具有高度自我更新和不定向分化的潜能,是形成不同分化程度肿瘤细胞和肿瘤不断扩展的源泉。多发性骨髓瘤(multiple myeloma,MM)肿瘤干细胞的发现以及对其与侧群(side population,SP)细胞的关系和龛(niche)等的相关研究为MM的发病机制提供了新的解释。
Cancer stem cells (CSCs) are a small group of stem cell-bearing tumor cells that exist in tumor tissues. They have the potential of highly self-renewal and non-directional differentiation, and are the sources of expanding tumor cells and tumors with different degrees of differentiation . The discovery of tumor stem cells in multiple myeloma (MM) and its relationship with side population (SP) cells and niche have provided a new explanation for the pathogenesis of MM.