论文部分内容阅读
用羊抗兔肾毒血清在兔诱发肾毒血清性肾炎，然后用致死剂量的Ｙ射线进行全身照射，以去除血中白细胞或静脉大剂量注射肝素，抑制纤维蛋白生成，从而抑制了肾毒血清性肾炎新月体的生成，并避免了晚期尿毒症的发生。结果表明，在肾毒血清性肾炎时，新月体细胞主要来源于血中单核细胞。而纤维蛋白作为一种趋化因子，吸引单核细胞进入肾小球球囊腔中，积聚形成新月体，单核细胞在吞噬纤维素过程中转变为上皮样细胞。
Sheep with anti-rabbit nephrotoxic serum induced nephrotoxic serum nephritis in rabbits, and then lethal dose of gamma rays for systemic irradiation to remove blood leukocytes or intravenous bolus injection of high-dose heparin to inhibit fibrin production, thereby inhibiting the nephrotoxic serum Nephritis of the formation of crescent and avoid the occurrence of advanced uremia. The results show that in nephrotoxic serum nephritis, crescent somatic cells mainly from blood mononuclear cells. Fibrin, as a chemokine, attracts mononuclear cells into the glomerular cavity of the glomerulus, accumulates to form crescents, and monocytes transform into epithelial-like cells during phagocytosis of cellulose.