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观察分析了18例骨髓增生异常综合征(MDS)的粒-单系祖细胞(CFU-GM)。其中4例同时作了CFU-GM及白血病祖细胞(CFU-L)动态观察,发现2例转变成急性白血病前,CFU-GM生长缺陷或丛样生长,并见CFU-L形成。另2例CFU-GM形成减少或生长缺陷。无CFU-L生长,临床病情相对稳定。结果表明骨髓CFU-GM丛样生长和CFU-L形成的MDS病人可能较快的发展成急性白血病。
18 cases of myelodysplastic syndrome (MDS) granulocyte-monocyte progenitor cells (CFU-GM) were observed and analyzed. CFU-L and CFU-L were also observed in 4 of them. CFU-L was observed in 2 cases of acute leukemia before they were found to have CFU-L growth defects or defects. The other two cases of CFU-GM formed a decrease or growth defects. No CFU-L growth, the clinical condition is relatively stable. The results showed that MDS patients with bone marrow CFU-GM cluster growth and CFU-L formation may rapidly develop acute leukemia.