论文部分内容阅读
有报道称与肿瘤穿透肽i RGD(CRGDK/RGPD/EC)联合用药能增强抗肿瘤药的疗效。本研究以荷B16-F10肿瘤的小鼠和裸鼠为模型,考察了i RGD修饰的多柔比星长循环脂质体(i RGD-SSL-DOX)与游离i RGD联用的疗效,以及i RGD修饰的SSL与游离i RGD或游离RGD联用的定位效果,以确定
It has been reported that the combination with the tumor-penetrating peptide i RGD (CRGDK / RGPD / EC) can enhance the antitumor effect. In this study, B16-F10 tumor-bearing mice and nude mice were used as models to investigate the efficacy of i RGD-modified doxorubicin long circulating liposomes (i RGD-SSL-DOX) in combination with free i RGD The positioning effect of RGD-modified SSL in combination with free i RGD or free RGD was determined