Skp2是F-box蛋白家族成员之一,参与多种细胞周期调节蛋白的泛素依赖性蛋白水解过程,从而调控细胞周期,并在多种肿瘤细胞中过表达。Skp2在前列腺癌的发生与发展、分级、分期、术后复发中起着重要的作用。探讨前列腺癌患者中Skp2的不同表达与疾病发生、进展及预后的关系,可进一步明确恶性肿瘤的发生机制,并可以作为抗肿瘤治疗的新靶点。 Skp2, a member of the F-box protein family, is involved in the ubiquitin-dependent proteolysis of a variety of cell cycle regulators that regulate the cell cycle and are overexpressed in a variety of tumor cells. Skp2 plays an important role in the occurrence and development of prostate cancer, grading, staging and postoperative recurrence. To explore the relationship between the different expression of Skp2 and the occurrence, progression and prognosis of patients with prostate cancer can further clarify the mechanism of malignant tumor and can be used as a new target of anti-tumor therapy.