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目的：探讨前列地尔（PGE1）联合美卡素在治疗早期糖尿病肾病（DN）中的临床疗效。方法收集住院66例早期DN患者，随机分为前列地尔组22例，美卡素组22例，联合组22例，进行4周临床观察治疗，分别比较三组血糖、尿素氮、血肌酐、尿肌酐、24 h尿蛋白定量、尿微量白蛋白水平的变化。结果治疗4周后，各组24 h尿蛋白定量及尿微量白蛋白等指标较治疗前均有明显好转（P﹤0.01）；而联合组的24 h尿蛋白定量及尿微量白蛋白较另两组改善更显著（P﹤0.01）。结论前列地尔联合美卡素治疗早期DN，能有效地发挥不同机理的协同作用，减少尿蛋白，更有助于延缓DN向中末期肾病发生和发展。“,”Objective To discuss the clinical effect of combined Alprostadil with Micardis in treating early diabetic nephropathy.Methods 66 inpatients with early diabetic nephropathy were divided into three groups randomly: PGE1 treatment group (n=22), Micardis treatment group (n=22) and combined treatment group (n=22), to compare respectively the change of blood glucose, urea nitrogen, serum creatinine, urine creatinine, quantitative test of 24 h urinary protein and urinary microalbumin level of three groups after 4 weeks clinical observation and treatment.Results After 4 weeks treatment, quantitative test of 24 h urinary protein, urinary microalbumin and other medical indicators of all three groups were clearly improved than before (P﹤0.01); quantitative test of 24 h urinary protein and urinary microalbumin of combined treatment group were much more improved than the other two groups (P﹤0.01).Conclusion Apply of combined Alprostadil with Micardis in treating early diabetic nephropathy could work out a different mechanism of synergistic effect, reduce urinary protein, and help better slowing down the occurrence and the development of diabetic nephropathy into mid-stage and end-stage renal disease.