目的研究经皮冠状动脉介入治疗(PCI)术前强化他汀治疗对老年冠心病患者术后生存状况的影响。方法将2014年2月至2015年1月本院收治的老年冠心病患者120例按随机数表法分为20 mg他汀组和40 mg他汀组,每组各60例。20 mg他汀组患者术前30分钟给予阿托伐他汀钙20 mg,40 mg他汀组患者术前30分钟给予阿托伐他汀钙40 mgo所有患者均于术前、术后12小时、24小时采集静脉血检测肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、超敏C反应蛋白(hs-CRP)水平,术前及术后24小时检测谷丙转氨酶(ALT)水平,观察PCI术后30天内主要心脏不良事件(MACE),包括心源性死亡、心肌梗死、再次靶血管血运重建发生情况。结果两组患者术后24小时CK-MB、cTnI水平较术前均显著升高(P<0.05),术后12小时、24小时hs-CRP水平较术前均显著升高(P<0.05),40 mg他汀组患者术后24小时CK-MB、cTnI、hs-CRP水平均显著低于20 mg他汀组(P<0.05);40 mg他汀组患者术后24小时ALT水平较术前显著升高(P<0.05),但平均值仍在正常范围内。20 mg他汀组患者术后30天内总心血管事件发生率明显高于40 mg他汀组(P<0.05)。。结论PCI术前强化他汀治疗能改善老年冠心病患者术后血流灌注,减少急性冠状动脉事件,建议作为老年冠心病患者PCI术前常规用药。 Objective To investigate the effect of percutaneous coronary intervention (PCI) on the survival status of elderly patients with coronary heart disease after intensive statin therapy. Methods A total of 120 elderly patients with coronary heart disease admitted to our hospital from February 2014 to January 2015 were randomly divided into 20 mg statin group and 40 mg statin group according to random number table. Patients in the 20 mg statin group were given 20 mg atorvastatin 30 minutes prior to surgery and 40 mg statin 40 mg atorvastatin 30 minutes prior to surgery. All patients were preoperatively, 12 hours and 24 hours postoperatively Serum CK-MB, cTnI, and hs-CRP were detected by venous blood test. ALT levels were measured before and 24 hours after operation. The major adverse cardiac events (MACE) within 30 days after PCI were observed, including cardiogenic death, myocardial infarction, and again target vessel revascularization. Results The levels of CK-MB and cTnI at 24 hours after operation in both groups were significantly higher than those before operation (P <0.05). The levels of hs-CRP at 12 hours and 24 hours after operation were significantly higher than those before operation (P <0.05) The levels of CK-MB, cTnI and hs-CRP in the 40 mg statin group were significantly lower than those in the 20 mg statin group at 24 hours after operation (P <0.05). The levels of ALT in the 40 mg statin group at 24 hours after operation were significantly higher than those before the operation High (P <0.05), but the average value is still within the normal range. The overall incidence of cardiovascular events within 30 days of the 20 mg statin group was significantly higher than that of the 40 mg statin group (P <0.05). . Conclusions The statin therapy before PCI can improve the postoperative blood perfusion in elderly patients with coronary artery disease and reduce the incidence of acute coronary events. It is recommended as a routine medication before PCI in elderly patients with coronary artery disease.