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目的探讨美托洛尔对高血压心脏病患者血压、QT间期离散度(QTd)及室性心律失常的影响。方法选取2014年5月—2015年5月江油市中医医院收治的高血压心脏病患者50例,采用随机数字表法分为对照组和观察组,每组25例。对照组患者给予常规治疗,观察组患者在常规治疗基础上给予美托洛尔治疗。比较两组患者治疗前后血压、QTd、室性心律失常发生率及临床疗效。结果两组患者治疗前收缩压、舒张压、QTd及室性心律失常发生率比较,差异无统计学意义(P>0.05);观察组患者治疗后收缩压、舒张压、QTd及室性心律失常发生率低于对照组(P<0.05)。观察组患者临床疗效优于对照组(P<0.05)。结论美托洛尔可有效降低高血压心脏病患者血压、QTd及室性心律失常发生率。
Objective To investigate the effects of metoprolol on blood pressure, QTd and ventricular arrhythmia in patients with hypertensive heart disease. Methods Fifty patients with hypertensive heart disease admitted to Jiangyou Hospital of Traditional Chinese Medicine from May 2014 to May 2015 were randomly divided into control group and observation group with 25 cases in each group. Patients in the control group were given conventional treatment, while patients in the observation group were given metoprolol on the basis of routine treatment. Blood pressure, QTd, ventricular arrhythmia incidence and clinical efficacy were compared between the two groups before and after treatment. Results There was no significant difference in the incidence of systolic blood pressure, diastolic blood pressure, QTd and ventricular arrhythmias between the two groups before treatment (P> 0.05). The systolic blood pressure, diastolic blood pressure, QTd and ventricular arrhythmia The incidence was lower than that of the control group (P <0.05). The clinical efficacy of the observation group was better than that of the control group (P <0.05). Conclusion Metoprolol can effectively reduce the incidence of hypertension, QTd and ventricular arrhythmia in patients with hypertensive heart disease.