Rwdd1, a Thymus Aging Related Molecule, Is a New Member of the Intrinsically Unstructured Protein Fa

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We had previously identified a novel protein termed Rwdd1 whose expression in thymus iS decreased in aged or oxidatively stressed mice.In the present study,we found that Rwdd1 expressed in both prokaryotic and eukaryotic cells showed a slower migration rate on SDS-PAGE gel.in addition,Rwdd1 was more sensitive to proteinase proteolysis.Furthermore,being a highly acidic protein which contains an RWD domain,Rwdd1 shared a high level of sequence similarity with Gir2,a member of the intrinsically unstructured protein(IUP).These findings suggest that Rwdd1 is a novel member of the IUP family.
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