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While the cervical mucosal immune response to human papillomavirus (HPV) infection is believed to be central to viral clearance, it is not well characterized. We performed this analysis to determine correlates of HPV- 16-specific mucosal antibody response in women at high risk for infection with HPV. Methods. Cervical mucosal and serum samples were obtained from participants in a case control study that measured demographic risk factors of cervical disease and HPV infection. An HPV- 16 L1-virus-like particle ELISA was used to detect HPV- 16-specific IgA and IgG. Antibody level results were correlated with demographic characteristics, sexual history, cervical disease, and HPV detection. Results. Cervical anti- HPV- 16 IgA and IgG inversely correlated with HPV DNA, HPV- 16 DNA, and cervical disease. Conclusions. Few studies provide serologic and mucosal antibody results in HPV- positive patients. There is a need for more longitudinal studies of HPV infection with verification of HPV positivity in tissue, measures of sera-positivity, measure-ments of mucosal immunity, and measurements of the cellular immune response.
While the cervical mucosal immune response to human papillomavirus (HPV) infection is believed to be central to viral clearance, it is not well characterized. We performed this analysis to determine correlates of HPV-16-specific mucosal antibody response in women at high risk for infection with HPV. Methods. Cervical mucosal and serum samples were obtained from participants in a case control study that measured demographic risk factors of cervical disease and HPV infection. An HPV- 16 L1-virus-like particle ELISA was used to detect HPV-16 Antibody level results were correlated with demographic characteristics, sexual history, cervical disease, and HPV detection. Results. Cervical anti-HPV-16 IgA and IgG inversely correlated with HPV DNA, HPV-16 DNA, and cervical disease Conclusions. Few studies provide serologic and mucosal antibody results in HPV-positive patients. There is a need for more longitudinal studies of HPV infection with verification of HPV posi tivity in tissue, measures of sera-positivity, measure-ments of mucosal immunity, and measurements of the cellular immune response.