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目的研究甲氰咪胍对胃粘膜血流的影响。方法激光多普勒血流仪检测甲氰咪胍对正常及梗阻性黄疸大鼠冷束缚应激时胃粘膜血流的影响。结果应激前用甲氰咪胍可使正常及梗阻性黄疸大鼠应激时胃粘膜血流增加(P<0.01),胃液 pH 升高(P<0.01),胃粘膜损伤减轻(P<0.05)。结论甲氰眯胍对胃粘膜血流有保护作用。
Objective To study the effect of cimetidine on gastric mucosal blood flow. Methods Laser Doppler flowmetry was used to detect the effect of cimetidine on gastric mucosal blood flow in cold and restraint rats with normal and obstructive jaundice rats. Results Cimetidine before stress increased gastric mucosal blood flow (P <0.01), gastric pH (P <0.01) and gastric mucosal lesion in normal and obstructive jaundice rats (P <0.05 ). Conclusion Amitraz is protective to gastric mucosal blood flow.