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目的 了解广东沿海地区吸毒人群中海洛因海绵状白质脑病的流行病学特点。方法 采用整群抽样对广东沿海地区 6市 18个戒毒所中 44 2 8名吸毒人员进行神经系统检查 ,发现异常者即查头颅MRI,凡有共济失调、MRI示大脑或小脑对称性脱髓鞘改变者纳入调查对象。结果 44 2 8名吸毒人群中发现了 14例海洛因海绵状白质脑病 ,总体发病率为 3.16‰ ;潮阳、河源两地患病率较高 ,其发病与吸毒方式有关。结论 该病仅见于经鼻烫吸患者 ,呈地区性小规模流行性发病 ,提示该病可能是由一种未明毒物引起的特殊类型的中毒性脑病 ,此毒物在吸毒者烫吸过程中产生 ,可能来源于某批毒品的添加剂。
Objective To understand the epidemiological characteristics of heroin causative leukoencephalopathy among drug users in the coastal areas of Guangdong. Methods A total of 44 28 drug addicts from 18 drug addicts in 6 cities in Guangdong coastal areas were enrolled in this study. The abnormalities were examined by craniocerebral MRI. All patients with ataxia and MRI showed demyelination of cerebellar or cerebellar symmetry Sheath changers were included in the survey. Results Forty-two cases of heroin causative disease were found in 44 28 drug addicts with an overall prevalence of 3.16 ‰. The prevalence rates of Chaoyang and Heyuan were higher, and the incidence was related to the mode of drug abuse. Conclusion The disease is only seen in patients with rhinosinusitis, showing a small-scale endemic disease, suggesting that the disease may be caused by a particular type of unspecified toxic encephalopathy, this poison in the drug addicts during hot suction, Drugs that may come from a batch of additives.