通过数学建模方法阐释干扰素-γ和白介素-6的信号交互机制

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：songtiger2222

【摘要】

：

干扰素-γ (IFN-γ)具有独特的抗病毒活性,能够促进免疫激活,抑制细胞的增殖,诱导细胞凋亡和癌症免疫应答。白介素-6(IL-6)在炎症和免疫应答中同样起到重要的调控作用,能够诱导细胞毒性T淋巴细胞分化、抑制细胞凋亡和增强自然杀伤细胞活性。研究表明,IFN-γ和IL-6信号刺激都可以激活蛋白酪氨酸激酶/信号转导和转录激活因子(JAK/STAT)通路,但它们所激活的STAT蛋白类型是不同的,这与I

【作者】

：

齐云峰

【机构】

：

吉林师范大学生命科学学院,四平,136000

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

系统生物学信号转导交互干扰素-γ 白介素-6

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通过数学建模方法阐释干扰素-γ和白介素-6的信号交互机制

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