RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via b

来源 :2016全国多糖研讨会 | 被引量 : 0次 | 上传用户：thomas962

【摘要】

：

　　Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target has been evaluated.Gal-3 is widely

【作者】

：

Lei Zhang Peipei Wang Yi Qin Qifei Cong Chenghao Shao Zhenyun Du Xinyan Ni Ping Li Kan Ding

【机构】

：

Glycochemistry&GlycobiologyLab,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,20

【出处】

：

2016全国多糖研讨会

【发表日期】

：

2016年10期

【关键词】

：

RN1 galectin-3 pancreatic cancer inhibitor Runx1

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target has been evaluated.Gal-3 is widely up-regulated in tumors,and its expression is associated with the development and malignancy of PDAC.In the present study,we demonstrate that a polysaccharide,RN1,purified from the flower of Panax notoginseng binds to Gal-3 and suppresses its expression.In addition,RN1 markedly inhibits PDAC cells growth in vitro,in vivo and in patient-derived xenografts(PDXs).

其他文献

Prediction of Structure Similarity of Metabolites via Tandem Mass Spectrometry Spectra Assists Ident

　　Tandem mass spectrometry(MS/MS)is frequently used for structural annotation of metabolites,because it provides abundance of structure information of metabol

会议

Tandem mass spectrometrystructure similarityidentification

A novel inorganic-organic hybrid polyoxometalateγ-cyclodextrin complexstructural characterization an

　　A novel non-covalent hybrid complex formed between silicotungstic acid(H4SiW12O40,SiW12,an abbreviation also for [SiW12O40]4-)and γ-cyclodextrin(γ-CD)was

会议

Polyoxometalate/cyclodextrin non-covalent complexstructural characterizationta

锆石Hf同位素LA-MC-ICP-MS分析及地质应用

　　锆石作为各类成因岩石中常见的副矿物，它的抗风化能力极强，具有较高的Hf 含量(0.5％～2％)和很高的Hf 同位素体系封闭温度，并且具有极低的Lu/Hf 比值，因此锆石是Hf 同位素分析的理

会议

锆石Hf同位素LA-MC-ICP-MS

Formation,Isomerization and Dissociation of Peptide Radical CationsStructural,Mechanistic,and Photod

　　Fundamental mass spectrometric studies of peptide radicals fragmentation is not just a scientific foundation for next-generation MS-based sequencing technol

会议

radical peptideion chemistrydistonic ionaction spectroscopy

Study on urine metabolic profile of Aβ25-35-induced Alzheimers disease by using UHPLC-Q-TOF-MS

　　Alzheimers disease(AD)is a progressive neurodegenerative disorder,with no effective method for its treatment so far.

会议

Aβ25-35Alzheimer's diseaseUHPLC-MSNeurotransmittersUrinary metabolomics

Investigation of Pathophysiological process and Plasma metabolomic analysis of Alzheimers disease ra

　　Alzheimers disease(AD)has become one of the major diseases endangering the health of the elderly,posing a heavy burden on elderly health care and socio-econ

会议

Alzheimer's disease ratpathophysiological processplasma metabolomicamylo

铜促进乙腈氮原子转移合成芳香腈化合物

C≡N 键与N≡N 键类似,均含有一个sp 杂化的N 原子,因此C≡N 键的活化为氮气的转化提供了一种可能的反应模型.近些年来,关于C≡N 键的完全断裂的研究受到了越来越多的重视.

会议

铜氮原子转移C≡N键断裂芳香腈化合物

Catalytic Asymmetric Hydrogenations and Kinetic Resolution

Chiral catalysts play a crucial role in the transition-metal-catalyzed asymmetric reactions,and many effective chiral catalysts have been synthesized over the p

会议

Design New Lattice Models to Study Real Polymers

Lattice models are ubiquitously used in theoretical and simulation studies of polymeric systems.Conventional lattice models use the self-and mutual-avoiding wal

会议

基于半刚性链模型的高分子结晶理论

　　我们在半刚性链模型的基础上，计算了片晶折叠链表面的界面自由能。自由能中的能量和熵的贡献分别来自排除体积相互作用和折叠表面链的loop构象熵的贡献。该体系具有链刚性

会议

结晶动力学单链平均场王-朗道算法

RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via b

与本文相关的学术论文