Changes in genes expression and aberrant promoter methylation during polypeptide from Chlamys farrer

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户:xuliangaihui
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: To establish a model that human HaCaT keratinocytes is transformed by multiple doses of UVB and investigate the mechanism of polypeptide from chlamys farreri (PCF) can inhibite the transformation of HaCaT cell induced by UVB irradiation.
其他文献
Fixed-dose combination finished pharmaceutical products (FDC-FPPs, FDCs) are fixed dose preparations with at least two active components.The objective of FDCs is to improve and enhance the whole effec
Aim: The main aim is to observe the changes in major pharmacological effect and safety of Chinese Meteria Medica injection (CMMI) when the macromolecular substances in them are removed.Methods: Two ki
Aim: To evaluate the bioactive monomer components of Radix Salviae Miltiorrhizae (RXM) by uniform design-high throughput screening (UD-HTS) method.Methods: Eleven of bioactive monomer components of RX
Aim: To discover novel PPARy modulator, PPARy-Gal4 chimera receptor and its mutant derivatives were applied to evaluate the binding activity of ligands and their molecular basis of interaction.Methods
Aim: Molecular descriptor is context-dependent, that is, the various interpretations of a specific molecular descriptor depend on the varying biological contexts.For example, molecular dipole can stan
Zebrafish as a vertebrate animal model is increasingly used for in vivo drug discovery and for assessing compound toxicity and safety, for its several compelling experimental advantages including tran
会议
Aim: A human monoclonal antibody was administered intravenously for 4-week in cynomolgus monkeys.The aim of this study was to characterize the toxicity of the antibody and in particular, the exposure-
Aim: Rho/Rho-kinase is an important new target for the treatment of cardiovascular diseases.The aim of this study was to investigate the cardiovascular protection effect of DL0805-2, a novel Rho-kinas
Aim: Contrast to its proliferation activity on breast cancer, the effects of estrogen on breast tumor cell motility or invasion are more poorly understood.Here, the roles of MRTF-A pathway, the key do
Aim: Parkinson disease (PD) is one of the most common neurodegenerative diseases characterized by progressive dopaminergic (DA) neuronal loss in the substantia nigra (SN).Tetrahydroxystilbene glucosid