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5. Increase of reactive oxygen species-mediated apoptosis by celastrol in taxol-sensitive and-resistant

Increase of reactive oxygen species-mediated apoptosis by celastrol in taxol-sensitive and-resistant

来源 :第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会 | 被引量 : 0次 | 上传用户：xuemun

【摘 要】

：

Objective: Taxol resistance is a major challenge in non-small cell lung cancer(NSCLC)treatment.In this study,the anti-cancer effect and mechanisms of celastrol(CEL),a triterpene molecule derived from

【作 者】

：

Zhao-Yu Wang Zheng-Hai Tang Wen-Xiang Cao Xiuping Chen Yi-Tao Wang Jin-Jian Lu 

【机 构】

：

State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,U

【出 处】

：

第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会

【发表日期】

：

2016年11期

【关键词】

：

Celastrol apoptosis ROS taxol 

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　　Objective: Taxol resistance is a major challenge in non-small cell lung cancer(NSCLC)treatment.In this study,the anti-cancer effect and mechanisms of celastrol(CEL),a triterpene molecule derived from Tripterygium wilfordii,in taxol-sensitive and-resistant NSCLC A549 cells were determined.

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