目的 研究溶质载体家族27成员5(Solute Carrier Family 27 Member 5,SLC27A5)在肝癌发生发展中的作用及其分子机制。方法 利用TCGA数据分析肝癌与癌旁组织中SLC27A5表达情况及其与预后的关系,并在临床肝癌标本中进行Western Blot和免疫组化验证;利用重组腺病毒和CRISPR/Cas9系统,分别建立SLC27A5过表达和基因敲除两种细胞模型,通过M
The TG interacting factor-1(TGIF1)protein in human is a transcription factor with essential roles in cell fate determination,and has been implicated in many human diseases including holoprosencephaly(
Monacolin J is a key precursor for the synthesis of simvastatin(Zocor),an important drug for treating hypercholesterolemia.Industrially,monacolin J is manufactured through alkaline hydrolysis of lovas
In this work,based on the high fluorescence quenching efficiency of polydopamine nanospheres(PDANS)and the specific recognition characteristic of aptamer,we construct a rapid,simple,sensitive and econ