Design and synthesis of a novel siRNA with propargyl analogs at their 3'-overhang

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  RNAi-based therapy has emerged as a powerful strategy for treatment of various diseases including cancer1.
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The exploration of RNA methylation was rejuvenated in the second decade of this century with the discovery of FTO as m6A demethylase in cells,which uncovered that RNA methylation is a dynamic and reve
FUS 是一种RNA 结合蛋白。它可以在细胞内形成功能性的无膜颗粒辅助RNA 行使功能,也会形成病理性聚集导致神经退行性疾病。细胞通过特定位点的丝氨酸/苏氨酸上的磷酸化来调控FUS 的组装形态,并抑制病理性聚集的产生。
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DNA guanine-rich sequences can form non-canonical secondary structures known as G-quadruplexes.It has been suggested that DNA G-quadruplexes are involved in several key biological processes and variou
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基因治疗是向病变细胞中导入正常基因以替换和修正病变基因,从而达到治疗的目的。由于磷酸基团的存在,核酸表面是带电负性的,同时,细胞表面有很多带负电荷的蛋白以及糖脂化合物,从而导致核酸很难直接通过胞吞作用进入细胞,因此,核酸能否顺利的进入细胞成为基因转染的难点。
Controlled drug release systems can enhance the safety and availability but avoid the side effect of drugs.Herein,we use the concept of DNA complementary base pairing rules in biology to design and pr
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会议
Owing to the complicated physiological microenvironment,nanosystems designed with the possibility of noninvasive real-time monitoring the therapeutic progression in the second near-infrared channel(NI