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The antidiabetic effects of the decoction of bitter melon(Momordica Charantia Linn.)pulps has been proven in vitro and in vitro by our previously studies,mainly on Type B diabetic subjects.The major active component of the decoction is Maillard reaction products (MRPs).The damage on pancreatic cells caused by free radicals is one of the major cellular pathological changes in diabetes.The effects of MRPs on this free radical induced cellular change was studied in order to illuminate the mechanism of MRPsantidiabetic effects.