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Antarctic and Southern Ocean science has been, and will continue to be, vital to understanding natural variability, the processes that govern change and the role of humans in the Earth system.The potential for new knowledge from Antarctic science yet to be conducted is substantial.Recognizing this promise, the international Antarctic community came together to scan the horizon to identify the highest priority scientific questions that Antarctic researchers should aspire to answer in the next two decades and beyond.Wide consultation was a fundamental precept to developing a collective, international view of future directions in Antarctic science.