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5. The γ-secretase blocker reduces the permeability of the blood-brain barrier by decreasing the ubiqui

The γ-secretase blocker reduces the permeability of the blood-brain barrier by decreasing the ubiqui

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：rocklysun

【摘 要】

：

Aim: Cerebral ischemia/reperfusion injury induces alterations in many signaling pathways that underlie BBB disruption and lead to neurovascular damage.We investigated the mechanisms of occludin degrad

【作 者】

：

Huan WANG Feng HAN Yun TIAN Rong-rong TAO Quan JIANG Ling-juan HONG Nan-nan LU Jing LI Shen LU Ying-mei LU 

【机 构】

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Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou,

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

permanent brain ischemia tight junction occludin DAPT ubiquitination degradation 

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Aim: Cerebral ischemia/reperfusion injury induces alterations in many signaling pathways that underlie BBB disruption and lead to neurovascular damage.We investigated the mechanisms of occludin degradation that underlie permanent middle cerebral artery occlusion (pMCAO) in rats.

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