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  5. Construction of Serum-resistance Cationic Polymer α-CD-PAMAM and evaluation of its performances as G

Construction of Serum-resistance Cationic Polymer α-CD-PAMAM and evaluation of its performances as G

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：xrong19730911
【摘 要】
：
Polyamidoamine(PAMAM)dendrimers as synthetic gene vectors have been proved to be efficient gene delivery systems.In this study,a kind of α-Cyclodextrin-PAMAM conjugates polymer was synthesized as gene
【作 者】
：
QIN Linghao CAO Duanwen PAN Shirong CHEN Jianhai 
【机 构】
：
Nanfang Hospital,Southern Medical University,Guangzhou,510515;School of pharmacy,Guangdong Pharmaceu
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
【发表日期】
：
2016年5期
【关键词】
：
Cyclodextrin polyamidoamine serum-resistance gene delivery 
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　　Polyamidoamine(PAMAM)dendrimers as synthetic gene vectors have been proved to be efficient gene delivery systems.In this study,a kind of α-Cyclodextrin-PAMAM conjugates polymer was synthesized as gene delivery vector.Based on 1H-NMR detectation,about 6.4 PAMAM-G1 molecules was grafted onto an α-CD core.Agarose gel electrophoresis results revealed that CyD-G1 could efficiently bind with DNA and condensed them into nano-scale particles which showed similar binding capacity of PEI-25K.Besides,it could protect DNA from DNaseⅠdegradation in a low N/P ratio.
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