【摘 要】
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Purpose:The purposes of this study of patients with rheumatic diseases in China were to determine treatment adherence and disease burden,analyze detailed medication problems experienced by these patie
【机 构】
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Department of Pharmacy,South Campus,Renji Hospital,School of Medicine,Shanghai Jiaotong University,S
【出 处】
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2017年中国药学大会暨第十七届中国药师周
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Purpose:The purposes of this study of patients with rheumatic diseases in China were to determine treatment adherence and disease burden,analyze detailed medication problems experienced by these patients,and identify factors associated with adherence.Patients and methods:Patients with confirmed diagnosesof ankylosing spondylitis(AS),rheumatoid arthritis(RA),and systemic lupus erythematosus(SLE)were recruited,regardless of demographics,disease severity,and treatment characteristics.Adherence was assessed using the Compliance Questionnaire for Rheumatology(CQR)and interview-based self-reports.A backwards-stepwise multivariate regression analysis was used to identify factors associated with adherence.Results:We collected data on 252 patients who had a rheumatic disease and visited our outpatient clinic in January or February of 2017.There were 121 patients with SLE,70 with RA,and 61 with AS.The overall adherence rate was 41.7%,and was 48.7%for SLE patients,38.6%for RA patients,and 31.1%for AS patients.The overall EuroQol(EQ)-index was 0.761; AS patients had the best EQ-index(0.792),followed by those with SLE(0.780)and RA(0.700).SLE patients also had greater annual direct costs($5103.58)than RA or AS patients.Conclusion:Overall,41.7%of our rheumatic disease patients were adherent,lower than in many other parts of the world.This indicatesit is important to identify methods that improve adherence in this population.It is particularly important to improve the health status and reduce the disease burden of patients with SLE,the most common of the three rheumatic diseases we analyzed.Our results suggest that reminder tools may improve adherence.Furtherprospective research is needed to confirm whether reminder tools and other measures can improve patient compliance.
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