Baekground: Autophagy, a highly conserved process conferring cytoprotection against stress, contributes to the progression of cerebral ischemia.β-arrestins are multifunctional proteins that mediate receptor desensitization and serve as important signaling scaffolds involved in numerous physiopathological processes.Methods and Results: Both ARRB1 (arrestin, beta 1) and ARRB2 (arrestin, beta 2) were upregulated by cerebral ischemic stress.